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The prescription drug Nitrolingual is approved to both treat chest pain (also known as angina) and prevent attacks from occurring due to strenuous physical activity. The medication is sprayed on or under the tongue, and you should refrain from rinsing out your mouth or spitting for at least 5 to 10 minutes after taking a dose. Common side effects include headaches and lightheadedness.

What Is Nitrolingual?

Nitrolingual® Pumpspray (nitroglycerin spray) is a prescription mouth spray that is used to treat attacks of chest pain (angina). It can also be used just before anticipated activity (usually physical exertion, such as exercise or sex) to help prevent chest pain.
(Click Nitrolingual Uses for more information on this topic, including possible off-label uses.)

Who Makes Nitrolingual?

Nitrolingual is made by Pohl-Boskamp GmbH & Co. KG for Arbor Pharmaceuticals, Inc.

How Does It Work?

Nitrolingual works by causing the veins and arteries of the body to relax. With the arteries and the veins in particular relaxed, the heart doesn't need to work so hard and doesn't require so much oxygen. Since angina is usually caused when there is not enough oxygen to meet the heart's needs, Nitrolingual can help to relieve angina attacks.

When and How to Take Nitrolingual

Some general considerations to keep in mind during treatment with Nitrolingual include the following:
  • This medication comes in the form of a liquid that is sprayed on or under the tongue.
  • You can use it up to 3 times within 15 minutes. If your chest pain isn't relieved after one spray, try another. If chest pain continues after a third spray, you should seek immediate medical attention.
  • Alternatively, Nitrolingual can be used 5 to 10 minutes before activity that is anticipated to cause chest pain.
  • Do not shake the bottle. The first time you use each bottle, you must prime it by spraying it five times into the air. Thereafter, you will need to reprime the bottle before use if you haven't used it in the past six weeks by spraying it once into the air. If it has been an especially long time since you last used Nitrolingual, the bottle might require up to five sprays to reprime it.
  • Do not rinse or spit for 5 to 10 minutes after using the spray.
  • For the medication to work properly, it must be taken as prescribed.
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Nitrolingual Spray Information

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