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Vitamin C Drug Interactions

Aluminum Products
Vitamin C can increase the absorption of aluminum (such as aluminum found in many antacids) into the body. For most people, this is not a problem, since the body adjusts by excreting more aluminum through the urine. However, high levels of aluminum could build up (and cause significant toxicity) in people with kidney disease.
There is some concern that vitamin C supplementation could make chemotherapy medications less effective. This is a controversial issue, and some researchers think that the opposite may be true (that vitamin C may make chemotherapy more effective). Until more information is available, you should check with your healthcare provider before taking vitamin C (especially high-dose vitamin C supplementation) if you are undergoing chemotherapy treatments.
When women who have a vitamin C deficiency start taking vitamin C, they may experience increases in the level of estrogen medications in the blood. This could increase the risk of estrogen side effects. This is not likely to be a problem for women who already have normal or high vitamin C intakes.
Protease Inhibitors
Vitamin C supplementation may slightly decrease the level of some protease inhibitor medications in the blood. It is not known if the effect is large enough to make the protease inhibitors less effective. If you take a protease inhibitor, it is probably a good idea to check with your healthcare provider before taking vitamin C (especially in high doses).
Warfarin (Coumadin, Jantoven)
Very high doses of vitamin C may make warfarin less effective, probably by causing diarrhea (which decreases the absorption of warfarin into the body). Check with your healthcare provider before taking warfarin and high doses of vitamin C together.
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