Verapamil Drug Interactions (Cont.)

 
Lithium (Eskalith, Eskalith CR, Lithobid)
Lithium can interact unpredictably with verapamil. Sometimes verapamil can make lithium less effective; other times, it can increase lithium toxicity. You should be monitored very carefully when you are taking these two medications together.
 
Phenobarbital (Luminal)
Phenobarbital may decrease the level of verapamil in your blood, perhaps making it less effective. Your healthcare provider may need to increase your verapamil dosage.
 
Quinidine
Verapamil can increase the level of quinidine in your blood, increasing your risk of side effects. Combining these two medications may also increase your risk of low blood pressure (hypotension). Be sure to talk with your healthcare provider before taking quinidine with verapamil.
 
Rifampin (Rifadin)
Rifampin can greatly decrease the level of verapamil in your blood, making it much less effective. In general, these medications should not be combined.
 
Theophylline
Verapamil can increase the level of theophylline in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor the level of theophylline in your blood, especially when starting or stopping verapamil.
 

Final Thoughts on Verapamil Drug Interactions

It is possible that not every verapamil drug interaction was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about drug interactions with verapamil that may apply to your situation.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;