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Verapamil Drug Interactions

Disopyramide (Norpace)
Because both disopyramide and verapamil decrease the heart's ability to pump blood forcefully, disopyramide should not be taken within 48 hours before, or 24 hours after, taking verapamil.
 
Flecainide (Tambocor)
Combining verapamil with flecainide may decrease the heart's ability to pump blood forcefully and may decrease the heart rate too much. Your healthcare provider should monitor you closely when combining these two medications.
 
Grapefruit Juice
Grapefruit juice can increase the level of verapamil in your blood, increasing your risk of side effects. Grapefruit juice should be avoided in most cases. However, if your healthcare provider decides that it is okay for you to drink grapefruit juice, you should do so consistently and in moderation.
 
Lithium (Eskalith, Eskalith CR, Lithobid)
Lithium can interact unpredictably with verapamil. Sometimes verapamil can make lithium less effective; other times, it can increase lithium toxicity. You should be monitored very carefully when you are taking these two medications together.
 
Phenobarbital (Luminal)
Phenobarbital may decrease the level of verapamil in your blood, perhaps making it less effective. Your healthcare provider may need to increase your verapamil dosage.
 
Quinidine
Verapamil can increase the level of quinidine in your blood, increasing your risk of side effects. Combining these two medications may also increase your risk of low blood pressure (hypotension). Be sure to talk with your healthcare provider before taking quinidine with verapamil.
 
Simvastatin
Verapamil increases the level of simvastatin in the blood, increasing the risk of serious side effects of simvastatin. If these medications are combined, the simvastatin dosage should not exceed 10 mg per day.
  
Telithromycin
Combining verapamil with telithromycin has been reported to cause low blood pressure (hypotension) and a slow heart rate (bradycardia). Check with your healthcare provider before taking these medications together.
  
Theophylline
Verapamil can increase the level of theophylline in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor the level of theophylline in your blood, especially when starting or stopping verapamil.
 
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Verapamil Hydrochloride (HCl)

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