The prescription drug trandolapril is licensed to treat several conditions related to the heart and blood vessels. Among these trandolapril uses are controlling high blood pressure and improving survival and/or decreasing the risk of developing congestive heart failure symptoms in people who have had a heart attack. Trandolapril increases the survival rate for people who develop heart failure or left ventricular dysfunction following a heart attack by up to 16 percent if taken on a daily basis. Trandolapril is not approved for use in children and has no universally accepted off-label uses.