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Rythmol SR Drug Interactions
Before your healthcare provider prescribes Rythmol SR, he or she will need to know whether you are taking any other antiarrhythmia medications, digoxin, or other drugs. Interactions with Rythmol SR can lead to potentially serious side effects, heart rhythm problems, or other complications. In some cases, your healthcare provider may need to closely monitor you and adjust the dosages of your medications.
Rythmol SR® (propafenone SR) can potentially interact with a few other medications. Some of the products that may lead to drug interactions with Rythmol SR include but are not limited to:
- Aripiprazole (Abilify®)
- Certain antiarrhythmia medications, such as:
- Amiodarone (Cordarone®, Pacerone®)
- Disopyramide (Norpace®, Norpace® CR)
- Dofetilide (Tikosyn®)
- Dronedarone (Multaq®)
- Ibutilide (Corvert®)
- Procainamide
- Quinidine
- Sotalol (Betapace®)
- Certain beta blockers, such as:
- Acebutolol (Sectral®)
- Betaxolol (Kerlone®)
- Bisoprolol (Zebeta®)
- Carvedilol (Coreg®, Coreg CR®)
- Esmolol (Brevibloc®)
- Labetalol (Trandate®)
- Metoprolol (Lopressor®, Toprol-XL®)
- Nebivolol (Bystolic®)
- Penbutolol (Levatol®)
- Propranolol (Inderal®, Inderal® LA, InnoPran XL™)
- Sotalol (Betapace®)
- Timolol
- Cimetidine (Tagamet®)
- CYP 1A2 inhibitor medications, such as:
- Ciprofloxacin (Cipro®, Cipro® XR)
- Fluvoxamine (Luvox®, Luvox® CR)
- Ketoconazole (Nizoral®)
- Lidocaine
- Methoxsalen (8-MOP®, Oxsoralen-Ultra®)
- Mexiletine
- Norfloxacin (Noroxin®)
- Ofloxacin (Floxin®)
- Primaquine
- CYP 2D6 inhibitor medications, such as:
- Bupropion (Aplenzin™, Budeprion SR®, Budeprion XL®, Buproban®, Wellbutrin®, Wellbutrin SR®, Wellbutrin XL®, Zyban®)
- Chlorpromazine
- Cinacalcet (Sensipar®)
- Cocaine
- Delavirdine (Rescriptor®)
- Fluoxetine (Prozac®, Sarafem®, Selfemra™)
- Lopinavir and ritonavir (Kaletra®)
- Paroxetine (Paxil®, Paxil CR®, Pexeva®)
- Quinidine
- Ritonavir (Norvir®)
- Terbinafine (Lamisil®)
- CYP 3A4 inducer medications, such as:
- Aminoglutethimide (Cytadren®)
- Bosentan (Tracleer®)
- Carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®)
- Dexamethasone (Decadron®, Dexpak®, Maxidex®)
- Efavirenz (Sustiva®)
- Efavirenz, emtricitabine, and tenofovir (Atripla®)
- Etravirine (Intelence®)
- Fosphenytoin (Cerebyx®)
- Nafcillin
- Nevirapine (Viramune®)
- Oxcarbazepine (Trileptal®)
- Pentobarbital (Nembutal®)
- Phenobarbital (Luminal®)
- Phenytoin (Dilantin®, Phenytek®)
- Primidone (Mysoline®)
- Rifabutin (Mycobutin®)
- Rifampin (Rifadin®)
- Rifapentine (Priftin®)
- St. John's wort (Hypericum perforatum)
- CYP 3A4 inhibitor medications, such as:
- Amprenavir (Agenerase®)
- Atazanavir (Reyataz®)
- Clarithromycin (Biaxin®)
- Conivaptan (Vaprisol®)
- Darunavir (Prezista®)
- Delavirdine (Rescriptor®)
- Erythromycin
- Fosamprenavir (Lexiva®)
- Imatinib (Gleevec®)
- Indinavir (Crixivan®)
- Isoniazid
- Itraconazole (Sporanox®)
- Ketoconazole (Nizoral®)
- Lopinavir and ritonavir (Kaletra®)
- Miconazole
- Nefazodone (Serzone®)
- Nelfinavir (Viracept®)
- Nicardipine (Cardene®)
- Posaconazole (Noxafil®)
- Quinidine
- Ritonavir (Norvir®)
- Saquinavir (Fortovase®, Invirase®)
- Telithromycin (Ketek®)
- Voriconazole (Vfend®)
- Desipramine (Norpramin®)
- Digoxin (Lanoxin®)
- Haloperidol (Haldol®)
- Imipramine (Tofranil®, Tofranil PM®)
- Medications that cause a certain change in the heart rhythm known as QT prolongation (see QT-Prolonging Medications for a list of these medications)
- Orlistat (Alli®, Xenical®)
- Theophylline (Uniphyl®, Theochron®, TheoCap®, Theo-24®, Elixophyllin®)
- Venlafaxine (Effexor®, Effexor XR®)
- Warfarin (Coumadin®, Jantoven®).
Written by/reviewed by: Susan Lakey, PharmD, MPH, BCPP
Last reviewed by: Kristi Monson, PharmD