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Drug Interactions With Propranolol
It's important to know that propranolol drug interactions can cause your body to metabolize certain medications differently and increase your risk of a very low heart rate or heart failure, among other things. Phenobarbital, disopyramide, fluvoxamine, and lidocaine are a few of the medications that can potentially interfere with propranolol. If drug interactions are a concern, your healthcare provider may monitor your situation more closely or adjust your dosages.
Propranolol hydrochloride (Inderal®) can potentially interact with a number of other medicines. Some of the medications that may lead to propranolol drug interactions can include:
- Alcohol
- Alpha blockers, including:
- Alfuzosin (Uroxatral®)
- Carvedilol (Coreg®)
- Doxazosin (Cardura®)
- Labetalol (Trandate®)
- Phenoxybenzamine (Dibenzyline®)
- Phentolamine (Regitine®)
- Prazosin (Minipress®)
- Tamsulosin (Flomax®)
- Terazosin (Hytrin®)
- Calcium channel blockers, such as:
- Amlodipine (Norvasc®)
- Diltiazem (Cardizem®, Cardizem CD®, Cardizem LA®, Cartia XT®, Dilacor XR®, Dilt-CD®, Diltia XT®, Dilt-XR®, Taztia XT®, Tiazac®)
- Felodipine (Plendil®)
- Isradipine (Dynacirc®, Dynacirc CR®)
- Nisoldipine (Sular®)
- Nicardipine (Cardene®, Cardene SR®)
- Nifedipine (Adalat CC®, Afeditab CR®, Nifediac CC®, Nifedical XL®, Procardia®, Procardia XL®)
- Nimodipine (Nimotop®)
- Verapamil (Calan®, Calan SR®, Covera-HS®, Isoptin SR®, Verelan®, Verelan PM®)
- Certain arrhythmia medications, including:
- Amiodarone (Cordarone®)
- Lidocaine (Xylocaine®)
- Propafenone (Rythmol®)
- Quinidine
- Clonidine (Catapres-TTS®, Catapres®, Duraclon®)
- Digoxin (Digitek®, Lanoxicaps®, Lanoxin®)
- Haloperidol (Haldol®)
- Monoamine oxidase inhibitors (MAOIs), including:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Rasagiline (Azilect®)
- Selegiline (Eldepryl®, Emsam®, Zelapar®)
- Tranylcypromine (Parnate®)
- Nonsteroidal anti-inflammatory drugs (NSAIDs), including (but not limited to):
- Diclofenac (Cataflam®, Voltaren®)
- Etodolac (Lodine®)
- Ibuprofen (Motrin®, Advil®)
- Indomethacin (Indocin®)
- Ketoprofen (Orudis®)
- Ketorolac (Toradol®)
- Nabumetone (Relafen®)
- Naproxen (Naprosyn®) or naproxen sodium (Aleve®, Anaprox®, Naprelan®)
- Oxaprozin (Daypro®)
- Celecoxib (Celebrex®)
- Meloxicam (Mobic®)
- Other beta blockers, including (but not limited to):
- Reserpine
- Thyroid medications, including:
- Liothyronine (Cytomel®)
- Liotrix (Thyrolar®)
- Levothyroxine (Levothroid®, Levoxyl®, Synthroid®, Tirosint®, Unithroid®)
- Thyroid (Armor® Thyroid, Nature-Throid®)
- Tricyclic antidepressants, including:
- Amitriptyline (Elavil®)
- Amoxapine (Asendin®)
- Clomipramine (Anafranil®)
- Desipramine (Norpramin®)
- Doxepin (Sinequan®, Silenor®)
- Imipramine (Tofranil®, Tofranil PM®)
- Maprotiline (Ludiomil®)
- Nortriptyline (Pamelor®)
- Protriptyline (Vivactil®)
- Trimipramine (Surmontil®)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD