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Drug Interactions With Propafenone

CYP 2D6 Inhibitor Medications
The liver breaks down propafenone using enzymes known as CYP 2D6 enzymes, and medications known as CYP 2D6 inhibitors can decrease the activity of these enzymes. Thus, combining propafenone with one of these drugs may increase the level of propafenone in your bloodstream, increasing your risk for side effects. Your healthcare provider may need to closely monitor you if you take these medicines together.
 
CYP 3A4 Inducer Medications
The liver breaks down propafenone using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining propafenone with one of these drugs may decrease the level of propafenone in your bloodstream, decreasing its effectiveness. Talk to your healthcare provider if you begin taking, or stop taking, a CYP 3A4 inducer during propafenone treatment.
 
CYP 3A4 Inhibitor Medications
The liver breaks down propafenone using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining propafenone with one of these drugs may increase the level of propafenone in your bloodstream, increasing your risk for side effects. Your healthcare provider may need to closely monitor you if you take these medications together.
 
Desipramine
Propafenone may increase the amount of desipramine in your bloodstream, which could increase your risk for side effects. Talk to your healthcare provider about this potential interaction before combining these drugs.
 
Digoxin
Combining digoxin with propafenone could increase your blood levels of digoxin. If you take digoxin, your healthcare provider may choose to monitor your blood level and adjust your dose if needed when you start or stop taking propafenone.
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Propafenone Drug Information

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