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Drug Interactions With Propafenone

More Detail on Drug Interactions With Propafenone

The following sections explain in detail the potentially negative interactions that can occur when propafenone is combined with any of the drugs listed above.
Propafenone may increase the level of aripiprazole in your blood, which could increase your risk for side effects. If you take aripiprazole, your healthcare provider may need to monitor you for side effects when you first start taking propafenone.
Certain Antiarrhythmics
Propafenone should not be used in combination with certain other arrhythmia medications due to the increased risk for a certain type of heart rhythm problem when these drugs are combined.
Certain Beta Blockers
Propafenone may increase blood levels of certain beta blockers. If you take a beta blocker medication, your healthcare provider may choose to monitor your heart rate and blood pressure closely and adjust your beta blocker dosage if needed when you first start or stop taking propafenone.
Cimetidine increases blood levels of propafenone, which increases the risk for potentially serious side effects. If you need a medication for acid reflux or heartburn during propafenone treatment, ask your healthcare provider or pharmacist about a drug that does not interact with propafenone.
CYP 1A2 Inhibitor Medications
The liver breaks down propafenone using enzymes known as CYP 1A2 enzymes, and medications known as CYP 1A2 inhibitors can decrease the activity of these enzymes. Thus, combining propafenone with one of these drugs may increase the level of propafenone in your bloodstream, increasing your risk for side effects. Therefore, your healthcare provider may need to closely monitor you if you take these medicines together.
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Propafenone Drug Information

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