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Side Effects of Omega-3-Acid Ethyl Esters

Side Effects With Omega-3-Acid Ethyl Esters to Report

There are a number of possible side effects with omega-3-acid ethyl esters that you should report immediately to your healthcare provider, including, but not limited to:
  • Chest pain
  • Signs of an allergic reaction, such as:


    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling (especially of the lips, mouth, or throat)
    • Wheezing or other breathing problems.


Theoretically, omega-3 medications could increase the risk of bleeding, although bleeding was not reported as an omega-3-acid ethyl esters side effect in clinical trials. Nonetheless, be sure to let your healthcare provider know if you notice any signs of bleeding, such as:
  • Easy bruising or bleeding
  • Black, tarry stools, bright-red blood in the stool, or vomiting of blood (signs of gastrointestinal bleeding)
  • Signs of a hemorrhagic stroke (bleeding in the brain), such as vision or speech changes, weakness or numbness in an arm or leg, or a severe headache.

Other Possible Omega-3-Acid Ethyl Esters Side Effects

Rarely reported omega-3-acid ethyl esters side effects include, but are not limited to:
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