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Nitrolingual Warnings and Precautions
If your chest pain continues even after three doses of Nitrolingual, this is a warning that you may be having a heart attack. In addition, certain precautions should be taken during treatment with this medication. This includes knowing that headaches are a common side effect and following your healthcare provider's dosing instructions exactly as prescribed.
You should talk with your healthcare provider prior to taking Nitrolingual® Pumpspray (nitroglycerin spray) if you have:
- Low blood pressure (hypotension)
- Dehydration
- Any allergies, including to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant
- Breastfeeding.
You should also be sure to tell your healthcare provider about all of the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.
Some warnings and precautions to be aware of before beginning treatment with Nitrolingual include the following:
- If you have used 3 sprays within 15 minutes and your chest pain continues, it is time to seek immediate medical attention. You may be having a heart attack.
- Do not use Nitrolingual more frequently or at a higher dose than absolutely necessary. Using it too frequently can result in tolerance to the drug, in which your body becomes accustomed to it and no longer responds to the medication.
- Nitrolingual can sometimes cause dangerously low blood pressure (hypotension). Alcohol or certain other medications may make this worse (see Nitrolingual Drug Interactions for more information). People who already have low blood pressure or who are dehydrated are at particular risk for this complication.
- Nitrolingual often causes headaches. Talk with your healthcare provider if the headaches become intolerable.
- This medication does not work for all types of chest pain (angina). If your chest pain gets worse when you use Nitrolingual, let your healthcare provider know right away.
- In rare cases, some people may be allergic to Nitrolingual. Let your healthcare provider know if you develop any signs of an allergic reaction, such as:
- Hives
- Itching
- Unexplained swelling
- Difficulty breathing.
- This product is a pregnancy Category C medication, which means that it may not be safe for use during pregnancy, although the full risks are currently unknown (see Nitrolingual and Pregnancy for more information).
- It is unknown if Nitrolingual passes through breast milk. Therefore, if you are breastfeeding or plan to start, check with your healthcare provider (or your child's healthcare provider) before taking this medication (see Nitrolingual and Breastfeeding).
Written by/reviewed by: Kristi Monson, PharmD
Last reviewed by: Kristi Monson, PharmD



