Nitrolingual Drug Interactions
Combining alcohol with Nitrolingual may increase the risk of low blood pressure (hypotension). Check with your healthcare provider before drinking alcohol while using Nitrolingual.
Based on reports of a drug interaction with intravenous (IV) nitroglycerin, it is possible that Nitrolingual could decrease the level of alteplase in the bloodstream, perhaps making it less effective. In the event that you need alteplase (which is sometimes used for people having a heart attack, blood clots, or certain types of strokes), make sure your healthcare provider knows you have been taking Nitrolingual.
Blood Pressure Medications
Combining Nitrolingual with blood pressure medications may cause a dangerously low blood pressure. Your blood pressure may need to be monitored more closely if you take these medications together.
Ergot medications may make Nitrolingual less effective for treating chest pain (angina), and Nitrolingual may increase the level of ergot medications in the blood, increasing the risk for ergot side effects. In general, this combination should be avoided if possible.
Phosphodiesterase Type 5 Inhibitors (PDE5 Inhibitors)
If you are taking Nitrolingual, you cannot take a PDE5 inhibitor, as dangerously low blood pressure may result. You cannot take these medications even within a few days of each other.
One study has suggested that people taking rosiglitazone with a nitrate (such as Nitrolingual) might be at an increased risk for poor blood flow to the heart, which may lead to a heart attack. It is not entirely clear if this finding is "real" or not.