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Nitroglycerin Spray
Nitroglycerin spray is available by prescription only and is used to treat or prevent chest pain (angina). The medication is sprayed on or under the tongue. You can use up to three sprays within 15 minutes. However, seek medical attention if your chest pain continues after the third spray. Possible side effects may include headaches, lightheadedness, and fainting.
Nitroglycerin spray (Nitrolingual®, NitroMist®) is a prescription mouth spray used to treat attacks of angina (chest pain due to inadequate blood supply to the heart). It can also be used just before anticipated activity (usually physical exertion, such as exercise or sexual intercourse) to help prevent chest pain.
(Click What Is Nitroglycerin Spray Used For? for more information on this topic, including possible off-label uses.)
Just like any medicine, nitroglycerin spray may cause side effects. However, not everyone who uses the drug will experience problems. In fact, most people tolerate it quite well.
If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious side effects are less common.
Common side effects of nitroglycerin spray include but are not limited to:
- Headaches
- Lightheadedness
- Low blood pressure (hypotension)
- Fainting.
(Click Nitroglycerin Spray Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by: Kristi Monson, PharmD
Last reviewed by: Kristi Monson, PharmD



