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Drug Interactions With Nitroglycerin Spray

Alcohol
Combining alcohol with nitroglycerin spray may increase your risk for low blood pressure (hypotension). Check with your healthcare provider before drinking alcohol while using this medicine.
 
Alteplase
Based on reports of a drug interaction with intravenous (IV) nitroglycerin, it is possible that nitroglycerin spray could decrease the level of alteplase in the bloodstream, perhaps making it less effective. In the event that you need alteplase, which is sometimes used for people who are having a heart attack, blood clots, or certain types of strokes, make sure your healthcare provider knows you have been using nitroglycerin spray.
 
Blood Pressure Medications
Combining nitroglycerin spray with blood pressure medications could cause dangerously low blood pressure. Your blood pressure may need to be closely monitored if you combine these medications together.
 
Ergot Medications
Ergot medications can make nitroglycerin spray less effective for treating chest pain (angina), and nitroglycerin spray may increase the level of ergot medications in the blood, increasing the risk for ergot side effects. In general, this combination of medications should be avoided if possible.
 
Phosphodiesterase Type-5 (PDE5) Inhibitors
If you are using nitroglycerin spray, you cannot take a PDE5 inhibitor, as dangerously low blood pressure may result. You cannot take these drugs even within a few days of each other.
 
Rosiglitazone
One study has suggested that people taking rosiglitazone with a nitrate, including nitroglycerin spray, have an increased risk for poor blood flow to the heart, which may lead to a heart attack.
 

Final Thoughts

It is possible that not all nitroglycerin spray drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.
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Nitroglycerin Spray Information

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