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Mexiletine Dosage

Taking mexiletine capsules every 8 or 12 hours can help stabilize the heart rate in people with potentially life-threatening ventricular arrhythmias. The initial recommended amount is usually 200 mg every eight hours. You will start the medicine in the hospital, so your healthcare provider can adjust your dose as needed. Your individual amount will depend on how you respond to the medicine and various other factors.

An Introduction to Your Dosage of Mexiletine

The dose of mexiletine (Mexitil®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • How you respond to the medication
  • Other drugs you are taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Mexiletine Dosing Guidelines

The recommended initial dose of mexiletine is usually 200 mg every eight hours. Your healthcare provider may increase this amount by 50 mg to 100 mg, no more often than every two to three days, until a dose is found that adequately controls your arrhythmia. If you experience certain dangerous or intolerable side effects, your healthcare provider may recommend you take a lower dose.
Most people can be adequately controlled on mexiletine doses between 200 mg and 300 mg every eight hours. People with severe liver disease or significant heart failure may need lower amounts. Doses should generally not exceed 400 mg every eight hours (1200 mg in a day).
People who are adequately controlled on dosages of 300 mg or less every 8 hours may be able to take mexiletine every 12 hours. If taken every 12 hours, doses should generally not exceed 450 mg every 12 hours (900 mg in a day).
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Mexiletine Drug Information

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