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Drug Interactions With Mexiletine

More Detail on Drug Interactions With Mexiletine

The following sections explain in detail the potentially negative interactions that can occur when mexiletine is combined with any of the drugs listed above.
 
Cimetidine
In some cases, cimetidine has been reported to affect mexiletine blood levels. However, because it is unclear how, or if, cimetidine will interact with mexiletine, your healthcare provider will need to carefully monitor you if you take these medications together. If you need a medication for heartburn or sour stomach, it may be best to choose a product other than cimetidine. Your healthcare provider can help you choose a similar medication that will not potentially react with mexiletine.
 
CYP 1A2 Inducer Medications
The liver breaks down mexiletine using enzymes known as CYP 1A2 enzymes, and medications known as CYP 1A2 inducers can increase the activity of these enzymes. Thus, combining mexiletine with one of these drugs may decrease the level of mexiletine in your bloodstream, potentially making it less effective. Your healthcare provider will need to closely monitor you, and possibly adjust your dose, if you take these drugs together.
 
CYP 1A2 Inhibitor Medications
The liver breaks down mexiletine using enzymes known as CYP 1A2 enzymes, and medications known as CYP 1A2 inhibitors can decrease the activity of these enzymes. Thus, combining mexiletine with one of these drugs may increase the level of mexiletine in your bloodstream, increasing your risk for side effects. Your healthcare provider will need to closely monitor you, and possibly adjust your dose, if you take these medications together.
 
CYP 2D6 Inhibitor Medications
The liver breaks down mexiletine using enzymes known as CYP 2D6 enzymes, and medications known as CYP 2D6 inhibitors can decrease the activity of these enzymes. Thus, combining mexiletine with one of these drugs may increase the level of mexiletine in your bloodstream, increasing your risk for side effects. Your healthcare provider will need to closely monitor you, and possibly adjust your dose, if you take mexiletine with a CYP 2D6 inhibitor.
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Mexiletine Drug Information

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