Drug Interactions With Metoprolol

Cimetidine (Tagamet)
If you are taking metoprolol and cimetidine together, your body may metabolize metoprolol differently than intended. This can cause an increased level of metoprolol in your body. If you are using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your metoprolol dose.
 
Clonidine
If you take both clonidine and metoprolol, stopping clonidine (without stopping metoprolol) could increase the risk of dangerously high blood pressure, strokes, and other serious problems. You should stop taking metoprolol several days before you gradually reduce the dose of clonidine. However, do not attempt this without the approval and supervision of your healthcare provider. If you are switching from clonidine to metoprolol, you should wait several days after stopping clonidine before starting metoprolol.
 
Digoxin
Combining metoprolol with digoxin may cause a dangerously slow heart rate (bradycardia). You may need to be monitored closely if you take these medications together. In some cases, they should not be combined.
 
Diphenhydramine (Banophen, Benadryl)
If you are taking metoprolol and diphenhydramine together, your body may metabolize metoprolol differently than intended. This can increase the level of metoprolol in your body. If you are using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your metoprolol dose.
 
Hydroxychloroquine (Plaquenil)
If you are taking metoprolol and hydroxychloroquine together, your body may metabolize metoprolol differently than intended. This can cause an increased level of metoprolol in your body. If you are using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your dose of metoprolol.
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Metoprolol Drug Information

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