Heart Disease Home > Ranexa Warnings and Precautions

Before prescribing Ranexa, your healthcare provider will need to know if you have liver disease or a certain heart problem called QT prolongation. There are other safety precautions to consider before taking Ranexa, including warnings against combining it with certain other medications and potential risks for women who are pregnant or nursing.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Ranexa® (ranolazine) if you have:
 
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • A heart problem known as QT prolongation or long QT syndrome
  • Any allergies, including to foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
 
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 

Specific Precautions and Warnings With Ranexa

Some warnings and precautions to be aware of prior to taking this drug include the following:
 
  • Ranexa can cause liver problems. In order to monitor for this, your healthcare provider should check your liver enzymes using a basic, standard blood test before you start Ranexa, once every three months for the first year, and then annually thereafter.
 
  • Ranexa can cause a change in the heart rhythm known as QT prolongation. QT prolongation increases the risk for life-threatening arrhythmias; however, studies have not shown that Ranexa increases the risk for arrhythmias. Combining Ranexa with other QT-prolonging medications might increase these risks.
 
 
  • Ranexa is a pregnancy Category C medication. This means that this drug might not be safe for use during pregnancy, although the full risks are currently unknown. Talk to your healthcare provider about the risks and benefits of using Ranexa during pregnancy (see Ranexa and Pregnancy for more information).
 
  • It is unknown if Ranexa passes through breast milk in humans. Therefore, if you are breastfeeding or plan to start, make sure to talk with your healthcare provider about using Ranexa (see Ranexa and Breastfeeding for more information).
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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