Heart Disease Home > Propafenone Dosage

The recommended starting dosage of propafenone for treating certain heart rhythm problems is usually 150 mg every eight hours. However, the specific amount will depend on how you respond to the medicine and various other factors. If necessary, this initial amount can be gradually increased up to a maximum of 300 mg every eight hours. Older adults and people with heart damage may need lower doses.

An Introduction to Your Dosage of Propafenone

The dose of propafenone (Rythmol®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • How you respond to the medication
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Propafenone Dosing Guidelines

The usual recommended initial propafenone dosage is 150 mg every eight hours. Your healthcare provider may gradually increase this amount, no more often than every three to four days, to 225 mg every eight hours. If necessary, the dosage may be increased again to 300 mg every eight hours, which is the maximum recommended dose.
You may need to begin treatment in a hospital setting, where you can be closely monitored until you are at an effective dose. Older adults and people with evidence of heart damage may need to start on lower amounts.

General Information on Taking Propafenone

Some considerations to keep in mind during treatment with propafenone include the following:
  • Propafenone comes in the form of a tablet. It is usually taken by mouth three times a day, every eight hours.
  • This medication can be taken with or without food. Try taking it with food if it seems to bother your stomach.
  • Take your doses of propafenone at the same time each day to keep an even level of the drug in your bloodstream.
  • For the medication to work properly, it must be taken as prescribed. Do not stop taking it, even if you feel well, as your irregular heartbeat may return.
  • If you are unsure about anything related to your dosage or propafenone dosing in general, please talk with your healthcare provider or pharmacist.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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