Heart Disease Home > Mexiletine Side Effects

Common Side Effects

Mexiletine has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking the drug were carefully documented and compared to those that occurred in a similar group of people taking a placebo (a "sugar pill" that does not contain any active ingredients) or another antiarrhythmia medication. As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo or the other medication.
In these studies, the most common mexiletine side effects included:
  • Gastrointestinal (GI) side effects, such as nausea, vomiting, heartburn, or indigestion -- in up to 39.6 percent of people
  • Lightheadedness or dizziness -- up to 26.4 percent
  • Shakiness (tremors) -- up to 13.2 percent
  • Nervousness -- up to 11.3 percent
  • Problems with coordination -- up to 9.7 percent
  • Feelings of a pounding or racing heart -- up to 7.5 percent
  • Chest pain (angina) -- up to 7.5 percent
  • Changes in sleep -- up to 7.5 percent
  • Headache -- up to 7.5 percent
  • Blurred vision -- up to 7.5 percent.
Other common reactions, occurring in 1.2 percent to 5.7 percent of people, included:
  • Shortness of breath
  • Weakness
  • Diarrhea
  • Rash
  • Body swelling
  • Constipation
  • Fatigue
  • Dry mouth
  • Numbness, pricking, or tingling sensations
  • Changes in appetite
  • Ringing of the ears
  • Confusion
  • Abdominal (stomach) pain or cramps
  • Joint pain
  • Depression
  • Difficulty speaking
  • Fever
  • Worsening arrhythmias.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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