Heart Disease Home > Mexiletine Side Effects

Common Side Effects

Mexiletine has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking the drug were carefully documented and compared to those that occurred in a similar group of people taking a placebo (a "sugar pill" that does not contain any active ingredients) or another antiarrhythmia medication. As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo or the other medication.
 
In these studies, the most common mexiletine side effects included:
 
  • Gastrointestinal (GI) side effects, such as nausea, vomiting, heartburn, or indigestion -- in up to 39.6 percent of people
  • Lightheadedness or dizziness -- up to 26.4 percent
  • Shakiness (tremors) -- up to 13.2 percent
  • Nervousness -- up to 11.3 percent
  • Problems with coordination -- up to 9.7 percent
  • Feelings of a pounding or racing heart -- up to 7.5 percent
  • Chest pain (angina) -- up to 7.5 percent
  • Changes in sleep -- up to 7.5 percent
  • Headache -- up to 7.5 percent
  • Blurred vision -- up to 7.5 percent.
 
Other common reactions, occurring in 1.2 percent to 5.7 percent of people, included:
 
  • Shortness of breath
  • Weakness
  • Diarrhea
  • Rash
  • Body swelling
  • Constipation
  • Fatigue
  • Dry mouth
  • Numbness, pricking, or tingling sensations
  • Changes in appetite
  • Ringing of the ears
  • Confusion
  • Abdominal (stomach) pain or cramps
  • Joint pain
  • Depression
  • Difficulty speaking
  • Fever
  • Worsening arrhythmias.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
Other Articles in This eMedTV Presentation
Advertisement


Topics

Medications

Quicklinks

Related Channels

eMedTV Links
Copyright © 2006-2019 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.