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More Detail on Drug Interactions With Metoprolol

The following sections explain in detail the potentially negative interactions that can occur when metoprolol is combined with any of the drugs listed above.
 
Alpha Blockers
Combining metoprolol with an alpha blocker can increase the risk of dangerously low blood pressure (hypotension). Check with your healthcare provider before taking such medications together.
 
Calcium Channel Blockers
Taking metoprolol with certain calcium channel blockers may cause dangerously low blood pressure and (for verapamil or diltiazem) a slow heart rate (bradycardia). You may need to be monitored closely if you take these medications together. In some cases, they should not be combined.
 
Certain Antidepressants
If you are taking metoprolol and certain antidepressants together, your body may metabolize metoprolol differently than intended. This can cause an increased level of metoprolol in your body. If you are using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your metoprolol dosage.
 
Certain Antipsychotics
If you are taking metoprolol and certain antipsychotics together, your body may metabolize metoprolol differently than intended. This can cause an increased level of metoprolol in your body. If you are using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your dose of metoprolol if needed.
 
Certain Arrhythmia Medications
Combining metoprolol with certain arrhythmia medications may cause a dangerously slow heart rate (bradycardia). You may need to be monitored closely if you take these medications together. In some cases, they should not be combined.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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