Heart Disease Home > Amlodipine


Amlodipine decreases blood pressure, reducing the risks that can occur with long-term high blood pressure (see Effects of High Blood Pressure). In clinical studies, amlodipine reduced systolic blood pressure by 12 points and diastolic blood pressure by 7 points (on average) in people with mild to moderate high blood pressure.
In people with exercise-induced angina (chronic stable angina), taking amlodipine increased the amount of time they could exercise before chest pain occurred.
For people with variant angina (Prinzmetal's angina), taking amlodipine decreased the number of angina attacks.

When and How to Take Amlodipine

Some general considerations for when and how to take the medication include:
  • Amlodipine comes in tablet form. It is taken by mouth, usually once a day.
  • You can take it with or without food. If it bothers your stomach, try taking it with food.
  • It should be taken at the same time each day to maintain an even level of the drug in your blood.
  • For amlodipine to work properly, it must be taken as prescribed. It will not work if you stop taking it.


The dose of amlodipine recommended by your healthcare provider will vary depending on a number of factors, including:
  • Your age
  • The medical condition you are being treated for
  • Other medical conditions
  • Other medications you may be currently taking.
As with any medication, do not adjust your amlodipine dose unless your healthcare provider specifically instructs you to do so.
(Click Amlodipine Dosage for more information.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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