Heart Disease Home > Amlodipine and Pregnancy

In animal studies on amlodipine, the medication increased miscarriages and prolonged labor when it was given to pregnant rabbits and rats. Due to these findings, the drug may not be safe for pregnant women. If you are taking amlodipine and pregnancy occurs, your healthcare provider will weigh the benefits and potential risks in your situation before making a recommendation.

Is Amlodipine Safe During Pregnancy?

Amlodipine besylate (Norvasc®) may not be safe for women to take when pregnant. This conclusion is based on animal studies that looked at the effects of amlodipine during pregnancy.

Amlodipine and Pregnancy Category C

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category C is given to medicines that have not been studied in pregnant humans but that do appear to cause harm to the fetus in animal studies. Also, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
Amlodipine was given a pregnancy Category C rating because of potential problems in animal studies. When given to pregnant rabbits and rats, amlodipine caused increased miscarriages. It also prolonged labor in rats. The medication did not cause any birth defects in animal studies.
However, it is important to note that animals do not always respond to medicines the same way that humans do. Therefore, a pregnancy Category C medicine may be given to a pregnant woman if the healthcare provider believes that the benefits to the woman outweigh any possible risks to the unborn child.

Final Thoughts

If you are pregnant or thinking of becoming pregnant while taking amlodipine, let your healthcare provider know. Your healthcare provider will consider the benefits and risks before making a recommendation in your particular situation.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):



Related Channels

eMedTV Links
Copyright © 2006-2020 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.