Heart Disease Home > Amiodarone Premixed Injection

How Does It Work?

Amiodarone premixed injection belongs to a group of medications known as antiarrhythmics. Most antiarrhythmic medications are further categorized using a system known as the Vaughn-Williams classification system. This system divides the medications into four general classes based on how they work.
 
Amiodarone premixed injection is considered a Class III antiarrhythmic; however, it has properties of all four classes and therefore works in several different ways. The most important way it works is by its Class III antiarrhythmic actions.
 
Class III antiarrhythmic medications block potassium channels in the heart, preventing potassium from leaving the cells of the heart muscle. This action prolongs the heart's refractory period, which is the period of time heart cells will not respond to a new electrical signal. By extending the refractory period, amiodarone premixed injection helps the heart tissue resist any electrical signal that is trying to come through prematurely.
 

When and How to Use This Medication

Some general considerations to keep in mind during treatment with amiodarone premixed injection include the following:
 
  • This medication comes as a liquid that is given as a slow injection into a vein (an intravenous, or IV, infusion). The injection is usually given through a tube inserted into a large vein in the chest.
 
  • You will receive this medicine in the hospital, where you will be closely monitored. You may need to remain in the hospital for one to three weeks.
 
  • Once your arrhythmia is stable, your healthcare provider may switch you over to amiodarone tablets. Make sure you understand the instructions for correctly using amiodarone tablets.
 
  • For the medication to work properly, it must be used as prescribed. Do not stop using this medication until your healthcare provider tells you to do so, as your irregular heartbeat may return.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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