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What Is Icosapent Ethyl Used For?

Icosapent ethyl can help treat extremely high triglyceride levels in adults. A healthcare provider may also recommend icosapent ethyl for "off-label" uses, such as treating moderately high triglycerides. This medicine contains an omega-3 fatty acid that is thought to help decrease the liver's production of triglycerides and break down triglycerides in the bloodstream.

An Overview of Uses for Icosapent Ethyl

Icosapent ethyl (Vascepa™) is a prescription fish oil medication approved for treating adults with extremely high triglycerides, defined as a triglyceride level of 500 mg/dL or higher. This medicine contains a highly refined form of the omega-3 fatty acid eicosapentaenoic acid (EPA).
 
Triglycerides are the main storage form of fat in the body and are important for the overall functioning of the body. However, high triglycerides in the blood (known as hypertriglyceridemia) can lead to health problems.
 
High triglycerides can increase your risk for developing certain medical conditions, including heart disease and heart attack. When triglycerides in the blood are high, they can build up on your artery walls, as can cholesterol and other debris. This buildup is called plaque.
 
Over time, plaque can narrow the blood vessels, and sometimes this buildup may even block your blood vessels completely. Plaque buildup on your blood vessel walls is called atherosclerosis.
 
For people with extremely high levels of triglycerides in the blood (over 1,000 mg/dL), high triglycerides can also cause other conditions, such as:
 
  • Xanthomas, which are fat deposits under the skin
  • Fatty liver
  • Pancreatitis, which is an inflammation of the pancreas.
 
Common causes of high triglycerides include obesity, inactivity, excessive alcohol consumption, or a high-carbohydrate diet. Other causes include various diseases and medications. In general, there are usually no noticeable symptoms of high triglycerides.
 
Before medications are prescribed to treat high triglycerides, your healthcare provider will recommend various lifestyle changes, such as changes in diet and exercise (see Diet to Lower Triglycerides). You should also limit your alcohol consumption and lose excess weight. Your healthcare provider will also check to make sure your high triglycerides are not caused by another disease or by a medication. After all of these efforts, medications like icosapent ethyl may be recommended if your triglycerides remain high.
 
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Icosapent Ethyl Drug Information

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