Fish Oil Drug Interactions (Cont.)

Fish Oil Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when fish oil is combined with any of the drugs listed above.
 
Aspirin
Theoretically, taking aspirin with fish oil may increase the risk of bleeding. However, some studies have not shown this to be a problem. If you take aspirin and fish oil together, let your healthcare provider know if you develop any unusual bruising or bleeding.
 
Blood Pressure Medication
Taking fish oil with high blood pressure medication may decrease your blood pressure too much, increasing the risk of low blood pressure (hypotension). Check with your healthcare provider before combining fish oil supplements with blood pressure medications, as your healthcare provider may need to monitor you more closely and adjust the dose of your blood pressure medication as necessary.
 
Clopidogrel (Plavix)
It is possible that clopidogrel may interact with fish oil, increasing your risk of bleeding. However, the significance of this interaction is not yet known. Check with your healthcare provider before taking clopidogrel and fish oil together.
 
Heparin and Heparin-Like Products
Theoretically, taking heparin with fish oil may increase the risk of bleeding. Check with your healthcare provider before taking fish oil and heparin together. If you know in advance that you will need to take heparin (such as for a surgery), it may be a good idea to temporarily stop taking fish oil.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDS)
Theoretically, taking an NSAID with fish oil may increase the risk of bleeding. If you take an NSAID regularly, you may want to check with your healthcare provider before taking fish oil.
(Fish Oil Drug Interactions Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;