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Drug Interactions With Felodipine

Felodipine Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when felodipine is combined with any of the drugs listed above.
 
Beta Blockers
Felodipine may increase the level of beta blockers (especially metoprolol) in the blood, which can increase your risk of felodipine side effects. Also, taking felodipine and beta blockers together can increase your risk of low blood pressure (hypotension). Your healthcare provider may need to adjust your dose of these medications.
 
Certain Antibiotics or Antifungals
Taking felodipine with certain antibiotics or antifungals can increase the level of felodipine in your blood, which may increase your risk of side effects. Your healthcare provider may need to monitor you more closely (and may need to lower your felodipine dose) while you are taking antibiotics or antifungal medications.
 
Certain Seizure Medications
Taking felodipine with certain seizure medications may decrease the level of felodipine in your blood, perhaps making it less effective. Your healthcare provider may need to increase your felodipine dosage.
 
Cimetidine (Tagamet)
Cimetidine can increase the level of felodipine in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your felodipine dose or may suggest one of the cimetidine alternatives.
 
Delavirdine (Rescriptor)
Taking felodipine with delavirdine can increase the level of felodipine in your blood, which may increase your risk of side effects. Your healthcare provider may need to monitor you more closely (and may need to lower your felodipine dose) while you are taking delavirdine.
 
Grapefruit Juice
Grapefruit juice may increase the level of felodipine in your blood, increasing your risk of side effects. This interaction is likely to occur even if you do not take felodipine at the same time of day as grapefruit juice. If your healthcare provider decides that it is okay for you to drink grapefruit juice, it is important to do so consistently and in moderation. It is probably safest to avoid grapefruit juice altogether while taking felodipine.
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