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What Is Dofetilide Used For?

How Does It Work?

Dofetilide belongs to a group of medications known as Class III antiarrhythmics. Class III antiarrhythmic medications block potassium channels in the heart, preventing potassium from leaving the heart muscle cells. This action extends the period of time that heart cells will not respond to a new electrical signal (known as the extended refractory period).
Atrial fibrillation or atrial flutter can occur when an electrical signal comes through too soon and prematurely activates heart tissue, leading to a rapid heart rate. By blocking potassium channels, dofetilide helps the heart tissue resist any premature electrical signal.

Can Children Use Dofetilide?

Dofetilide has not been adequately studied in children, and is not approved for use in individuals younger than 18 years of age. Talk to your child's healthcare provider about the risks and benefits of using this medicine in children.

Is It Safe for Older Adults?

Older adults can use dofetilide. In general, because older adults are more likely to have reduced kidney function, they may need a lower dofetilide dosage.

What About Off-Label Dofetilide Uses?

On occasion, a healthcare provider may recommend this medication for treating something other than the conditions discussed in this article. This is called an "off-label" use. Dofetilide may be used off-label to treat:
  • Ventricular arrhythmias (abnormal heartbeat of the ventricles)
  • Supraventricular arrhythmias (abnormal heartbeat starting above the ventricles)
  • Wolff-Parkinson-White syndrome.
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Dofetilide Medication Information

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