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Drug Interactions With Dofetilide

Prochlorperazine
Prochlorperazine may increase blood levels of dofetilide, potentially increasing the risk for dofetilide side effects, including potentially serious side effects. These medicines should not be used together.
 
Quinine
In general, you should not take quinine in combination with dofetilide because of an increased risk for a life-threatening abnormal heartbeat (heart arrhythmia) if these medicines are used together.
 
Thiazide Diuretics
Combining dofetilide with a thiazide diuretic can increase your risk for a potentially life-threatening abnormal heartbeat. The manufacturer of dofetilide recommends it not be taken with hydrochlorothiazide. You should talk to your healthcare provider before taking dofetilide with any of the thiazide diuretics listed above.
 
Toremifene
In general, you should not take toremifene in combination with dofetilide because of an increased risk for a life-threatening heart rhythm problem if these medicines are used together.
 
Triamterene
Triamterene may increase blood levels of dofetilide, potentially increasing the risk of dofetilide side effects. Your healthcare provider may need to monitor you more closely if you take dofetilide with triamterene. Dofetilide should not be used in combination with triamterene/HCTZ.
 
Trimethoprim
Trimethoprim increases the amount of dofetilide in the blood, potentially increasing the risk for a dangerous heart rhythm problem. These medicines should not be taken together.
 
Verapamil
Verapamil increases blood levels of dofetilide, increasing the risk for a dangerous heart rhythm problem. You should not take these drugs together.
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Dofetilide Medication Information

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