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Drug Interactions With Dofetilide

More Information on Drug Interactions With Dofetilide

The following sections explain in detail the potentially negative interactions that can occur when dofetilide is combined with any of the drugs listed above.
 
Amiloride
Amiloride may increase blood levels of dofetilide, which could increase the risk for dofetilide side effects. Your healthcare provider may choose to monitor your heartbeat more closely if you take these medicines together. Because people taking dofetilide should not take hydrochlorothiazide (HCTZ), dofetilide should not be taken with the combination product amiloride-HCTZ.
 
Artemether
Combining artemether with dofetilide could increase your risk for a potentially life-threatening heart rhythm problem. These medicines should not be taken together.
 
Certain Antifungal Medications
Certain antifungal medicines may increase the level of dofetilide in the bloodstream, potentially increasing the risk for a dangerous abnormal heartbeat. The manufacturer of dofetilide recommends not using it with ketoconazole. In general, all of the antifungals listed above (known as "azole antifungals") should be avoided when taking dofetilide.
 
Cimetidine
Cimetidine increases blood levels of dofetilide, which increases the risk for a potentially life-threatening abnormal heartbeat. You should not take these drugs together. If you need a medication for reflux, ask your healthcare provider or pharmacist about an alternative medicine that is safe for use with dofetilide.
 
CYP 3A4 Inhibitor Medications
The liver breaks down dofetilide using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining dofetilide with one of these drugs may increase the level of dofetilide in your bloodstream, increasing your risk for side effects. The manufacturer of dofetilide recommends it be used cautiously in combination with CYP 3A4 inhibitors. Therefore, your healthcare provider may need to closely monitor you if you take these drugs together.
 
Dolutegravir
Dolutegravir may increase blood levels of dofetilide, increasing the risk for a dangerous heart rhythm problem. These medicines should not be used together.
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Dofetilide Medication Information

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