Diltiazem

Diltiazem is a prescription medication used for controlling high blood pressure and treating certain types of chest pain. The medication is a type of calcium channel blocker that helps to relax the blood vessels to improve blood flow. Although most people do not have any problems taking the medication, there are potential side effects, such as swelling, headaches, and dizziness. Diltiazem is available as a tablet or capsule and is taken one to four times a day.

 

What Is Diltiazem?

Diltiazem hydrochloride is a prescription medication used to treat high blood pressure (hypertension) and certain types of chest pain (angina).
 
(Click Diltiazem Uses for more information on what it is used for, including possible off-label uses.)
 

Different Versions of Diltiazem

There are many different versions of diltiazem.
 Some are equivalent to each other, while others are not. To make matters even more confusing, many manufacturers of generic diltiazem have chosen to give their medications different names (which makes them sound like brand-name medications). Not all diltiazem medications are approved for the same uses, and the dosages may be different. Different versions of diltiazem include:
 

How Does It Work?

Diltiazem is part of a class of drugs called calcium channel blockers. It helps to slow down the rate at which calcium moves into your heart and blood vessel walls. This, in turn, helps to relax the blood vessels, which improves blood flow and lowers blood pressure. This also makes it easier for the heart to pump blood.
 
There are two basic types of calcium channel blockers: dihydropyridine and non-dihydropyridine. The most important difference between the two types is that non-dihydropyridine calcium channel blockers can slow down the heart rate, while dihydropyridine calcium channel blockers do not. Diltiazem is a non-dihydropyridine calcium channel blocker, which means that it can decrease the heart rate. Because of this, it is useful for treating certain types of irregular heart rhythms (arrhythmias).
 

When and How to Take Diltiazem

Some general considerations for when and how to take the medication include:
 
  • Diltiazem comes in the form of a capsule or tablet. It is taken by mouth, one to four times daily, depending on the particular product.
     
  • You can take most diltiazem products with or without food. However, Dilacor XR, Diltia XT, and Dilt-XR capsules should be taken on an empty stomach. Regular Cardizem tablets (not Cardizem CD or Cardizem LA) should be taken before meals.
     
  • Diltiazem capsules are extended release and should not be crushed or chewed. Be sure to swallow them whole. However, Tiazac and Taztia XT capsules can be opened, and you can sprinkle the contents onto a spoonful of applesauce. The applesauce should not be hot, and you should immediately swallow it whole (without chewing); follow the applesauce with a glass of water.
     
  • Cardizem LA tablets are extended release and should not be cut, crushed, or chewed.
     
  • Diltiazem should be taken at the same time(s) each day to maintain an even level of the drug in your blood.
     
  • For the medicine to work properly, it must be taken as prescribed. It will not work if you stop taking it.
     

Dosing

The dose of diltiazem your healthcare provider recommends will vary depending on a number of factors, including:
 
  • The particular diltiazem product
  • The medical condition being treated
  • Other medical conditions you have
  • Other medications you are currently taking.
     
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 
(Click Diltiazem Dosage for more information about this topic.)
 

Side Effects

As with any medicine, there are possible side effects with diltiazem. However, not everyone who takes the medication will experience side effects. In fact, most people tolerate it quite well. When side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider. Serious side effects are less common.
 
Common side effects of diltiazem include, but are not limited to:
 
  • Swelling or water retention in the hands, feet, or lower legs (edema)
  • Dizziness
  • Headaches.
     
(Click Diltiazem Side Effects to learn about specific side effects of the drug, including serious side effects to look out for. You can also read about possible side effects by going to:
 

Drug Interactions With Diltiazem

Diltiazem can potentially interact with a number of medicines.
 
(Click Diltiazem Drug Interactions for more information about these possible interactions.)
 

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking diltiazem if you have:
 
Also, let your healthcare provider know if you are:
 
Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
(Click Diltiazem Precautions and Warnings for more information on this topic, including information on who should not take diltiazem.)
 

Overdose

People who take too much diltiazem may have overdose symptoms that could include:
 
  • Extremely low blood pressure (hypotension)
  • Heart failure
  • A slow heart rate (bradycardia).
     
If you happen to overdose, seek immediate medical attention.
 
(Click Diltiazem Overdose for more information.)
 

Storage Methods

The medication should be stored at room temperature, away from moisture and heat. Diltiazem tablets and capsules should be stored in an airtight container.
 
Keep diltiazem and all medications out of the reach of children.
 

What Should I Do If I Miss a Dose?

If you do not take your dose as scheduled, take your missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose of diltiazem.
 

Generic Diltiazem

Currently, many (but not all) brand-name diltiazem products have generic versions available.
 
(Click Generic Diltiazem for more information.)
 
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;