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Diltiazem Drug Interactions

Digoxin (Digitek, Lanoxin)
Diltiazem may increase the level of digoxin in your blood (although studies have shown conflicting results). Because changes in digoxin levels can be dangerous, your healthcare provider should monitor the level of digoxin in your blood and adjust your digoxin dosage as necessary. Your healthcare provider should also monitor your heart rate, as diltiazem and digoxin can both lower your heart rate.
 
Quinidine
Diltiazem can increase the level of quinidine in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your quinidine dosage.
 
Rifampin (Rifadin)
Rifampin can greatly decrease the level of diltiazem in your blood, making it much less effective. In general, these medications should not be combined.
 
Some Statins
Diltiazem can increase the level of certain statin medications in the blood, perhaps increasing the risk of side effects. Your healthcare provider may need to adjust your statin dosage or may recommend that you switch to a different statin that does not interact with diltiazem.
  

Final Thoughts on Diltiazem Drug Interactions

It is possible that not every diltiazem drug interaction was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about drug interactions with diltiazem that may apply to your situation.
 
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