DHA Drug Interactions (Cont.)

DHA Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when DHA is combined with any of the drugs listed above.
 
Aspirin
Theoretically, taking aspirin with fish oil (which contains DHA) may increase the risk of bleeding. However, it is not clear if DHA alone also has this problem. If you take aspirin and DHA together, let your healthcare provider know if you develop any unusual bruising or bleeding.
 
Blood Pressure Medication
Taking fish oil (which contains DHA) with high blood pressure medication may decrease your blood pressure too much, increasing the risk of low blood pressure (hypotension). However, it is not known if this interaction applies to DHA alone. Check with your healthcare provider before combining DHA supplements with blood pressure medication, as your healthcare provider may need to monitor you more closely and adjust the dose of your blood pressure medication as necessary.
 
Clopidogrel (Plavix)
It is possible that clopidogrel may interact with fish oil (which contains DHA), increasing your risk of bleeding. It is not yet known if this interaction applies to DHA alone. Check with your healthcare provider before taking clopidogrel and DHA together.
 
Heparin and Heparin-Like Products
Theoretically, taking heparin with fish oil (which contains DHA) may increase the risk of bleeding, although it is not known if this is also true for DHA alone. Check with your healthcare provider before taking DHA and heparin together. If you know in advance that you will need to take heparin (such as for a surgery), it may be a good idea to stop taking DHA temporarily.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDS)
Theoretically, taking an NSAID with fish oil (which contains DHA) may increase the risk of bleeding. It is not clear if DHA alone also causes this problem. If you take an NSAID regularly, you may want to check with your healthcare provider before taking DHA.
(DHA Drug Interactions Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;