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Coreg CR Drug Interactions

Certain Diabetes Medications
Coreg CR could increase the risk of dangerously low blood sugar (hypoglycemia) that can occur with some diabetes medications. Additionally, Coreg CR can mask some of the symptoms of low blood sugar (such as a rapid heart rate), making it less noticeable. This can lead to a very dangerous situation. You may need to monitor your blood sugar more closely, especially when starting or stopping Coreg CR (or even when changing your dosage).
 
Cimetidine (Tagamet)
If you are taking Coreg CR and cimetidine together, your body may metabolize Coreg CR differently than intended. This can cause an increased level of Coreg CR in your body. If you are using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your Coreg CR dose if needed.
 
Clonidine
If you take both clonidine and Coreg CR, stopping clonidine (without stopping Coreg CR) could increase the risk of dangerously high blood pressure, strokes, and other serious problems. It is advised to stop taking Coreg CR several days before you gradually reduce the dose of clonidine. Do not attempt this without the approval and supervision of your healthcare provider. If you are switching from clonidine to Coreg CR, it is advised to wait several days after stopping clonidine before starting Coreg CR.
 
Cyclosporine
Coreg CR may increase the level of cyclosporine in your blood. Your healthcare provider should monitor your cyclosporine levels and adjust your cyclosporine dosage as necessary.
 
Digoxin
Combining Coreg CR with digoxin may cause a dangerously slow heart rate (bradycardia). Additionally, Coreg CR may increase the level of digoxin in the blood. You may need to be monitored very closely if you take these medications together. In some cases, it is not recommended to combine Coreg CR with digoxin.
 
Diphenhydramine
If you are taking Coreg CR and diphenhydramine together, your body may metabolize Coreg CR differently than intended. This can increase the level of Coreg CR in your body. If you are using these medicines together, your healthcare provider may choose to monitor you more closely and/or adjust your Coreg CR dose if needed.
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Coreg CR Medication Information

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