There are no established CoQ10 dosing guidelines because the supplement is still in the early stages of research. Also, there is significant variability in the absorption of different supplements -- a supplement that is better absorbed may require a lower dosage. Some studies have used a wide range of dosage amounts, ranging from 60 mg per day up to 3000 mg per day.
An Introduction to Dosing With CoQ10
The best dose of CoQ10 (coenzyme Q10) has not yet been determined for treating a variety of health conditions. Research for several different conditions is only in the early stages -- too early to recommend dosages that are safe and effective.
Also, there may be significant variability in the absorption of different CoQ10 supplements, which could significantly affect dosage recommendations. Lastly, people may have varying levels of CoQ10 needs and different levels of CoQ10 deficiencies, and what may be best for one person may not be best for another.
CoQ10 Absorption Issues
It is thought that fat may help with the absorption of CoQ10 into the bloodstream. Supplements that are formulated in soybean oil or other fatty substances may be better absorbed than other types of supplements. Taking CoQ10 with a fat-containing meal may also increase absorption. However, more research is necessary in this area.
Because of the potential differences in absorption, it can be difficult to directly compare different CoQ10 supplements. This also causes difficulties when recommending dosages of CoQ10, as some people may need higher doses of a poorly absorbed CoQ10 supplement than they would of a well-absorbed supplement.
Studies have used a wide range of CoQ10 doses, from as low as 60 mg per day up to 3000 mg per day. Typically, high doses were used for conditions such as Parkinson's disease or mitochondrial diseases, and low doses were used for most other conditions. Because there are so many variables, such as the content and absorption of your particular CoQ10 supplement, it is reasonable to follow the directions on the label of your particular product. Do not exceed these recommendations, unless your healthcare provider specifically instructs you to do so.