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Drug Interactions With Clopidogrel

Drug interactions with clopidogrel may involve medications such as warfarin, nonsteroidal anti-inflammatory drugs (NSAIDs), and phenytoin. For example, taking clopidogrel and warfarin together may cause the body to metabolize both medications differently than intended, and taking nonsteroidal anti-inflammatory drugs (NSAIDs) with clopidogrel can increase the risk of bleeding. Herbal and nutritional supplements can also interact with clopidogrel and possibly increase the risk of bleeding.

An Introduction to Clopidogrel Drug Interactions

Clopidogrel bisulfate (sold under the brand name Plavix®) has a number of medicines that it can potentially interact with. Some of these drug interactions with clopidogrel involve medications such as:
  • Fluvastatin (Lescol®)  
  • Medications that "thin" the blood (such as anticoagulant and antiplatelet drugs) or otherwise increase bleeding risk, such as:
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)


Several herbal and nutritional supplements can also interact with clopidogrel and may increase the risk of bleeding. Examples of these include, but are not limited to:
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Clopidogrel Bisulfate

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