Drug Interactions With Clopidogrel

Drug interactions with clopidogrel may involve medications such as warfarin, nonsteroidal anti-inflammatory drugs (NSAIDs), and phenytoin. Taking clopidogrel and warfarin together may cause the body to metabolize both medications differently. Also, taking nonsteroidal anti-inflammatory drugs (NSAIDs) with clopidogrel can increase the risk of bleeding. Herbal and nutritional supplements can also interact with clopidogrel and possibly increase the risk of bleeding.

Clopidogrel Bisulfate

Drug Interactions With Clopidogrel: An Introduction

Clopidogrel bisulfate (sold under the brand name Plavix^®) has a number of medicines that it can potentially interact with. Some of these drug interactions with clopidogrel involve medications such as:

Warfarin (Coumadin^®, Jantoven^®)

Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil^®, Motrin^®), naproxen (Aleve^®, Naprosyn^®, Anaprox^®, Naprelan^®), meloxicam (Mobic^®), indomethacin (Indocin^®), nabumetone (Relafen^®), and oxaprozin (Daypro^®)

Phenytoin (Dilantin^®)

Tamoxifen (Nolvadex^®)

Torsemide (Demadex^®)

Fluvastatin (Lescol^®).

Several herbal and nutritional supplements can also interact with clopidogrel and may increase the risk of bleeding. Examples of these include, but are not limited to:

Dong quai
Feverfew
Garlic
Ginger
Ginkgo biloba
Ginseng
St. John's wort
Fish oil supplements.

(Drug Interactions With Clopidogrel Continued: Page 2)