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Drug Interactions With Clopidogrel

More Details on Clopidogrel Interactions

The following sections explain in detail the potentially negative interactions that can occur when clopidogrel is combined with any of the drugs listed previously.
 
CYP 2C19 Inhibitors
Clopidogrel is metabolized into its active form by certain liver enzymes known as CYP 2C19 enzymes. Certain other medications inhibit these enzymes, perhaps decreasing the effectiveness of clopidogrel. In general, it is usually best to avoid taking clopidogrel with such medications.
 
Fluvastatin
Taking clopidogrel and fluvastatin together can increase the amount of fluvastatin in your blood, resulting in possible side effects. Check with your healthcare provider before taking fluvastatin and clopidogrel together.
 
Medications That Increase Bleeding Risk
Taking clopidogrel with medications like anticoagulants (blood thinners), other antiplatelet drugs, or any other type of medication that can increase the risk of bleeding may increase your risk of dangerous internal bleeding. Clopidogrel is intended to be used along with aspirin in certain situations. Check with your healthcare provider if you are unsure if you should be taking aspirin with clopidogrel.
  
Phenytoin
Taking clopidogrel and phenytoin together can increase the amount of phenytoin in your blood, resulting in possible side effects. Check with your healthcare provider before taking phenytoin and clopidogrel together.
 
Tamoxifen
Taking clopidogrel and tamoxifen together can increase the amount of tamoxifen in your blood, resulting in possible side effects. Check with your healthcare provider before taking tamoxifen and clopidogrel together.
 
Tolbutamide
Taking clopidogrel and tolbutamide together can increase the amount of tamoxifen in your blood, resulting in possible side effects. Check with your healthcare provider before combining these medications.
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