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Precautions and Warnings With Choline Fenofibrate

If you have liver problems, gallbladder disease, or any allergies, talk to your healthcare provider before using choline fenofibrate. This product can be effective for high cholesterol and triglycerides, but it is not appropriate for everyone. To help ensure a safe treatment with choline fenofibrate, discuss the warnings and precautions with your healthcare provider to make sure this drug is right for you.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking choline fenofibrate (Trilipix®) if you have:
  • Gallbladder disease, including gallstones
  • Liver disease, liver failure, or a history of liver disease
  • Kidney disease or kidney failure
  • Any allergies, including to foods, dyes, or preservatives.
In addition, let your healthcare provider know if you are:
  • Pregnant or thinking about becoming pregnant
  • Breastfeeding.
Also, tell your healthcare provider about all other medicines you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements. 

Specific Warning and Precautions With Choline Fenofibrate

Some precautions and warnings to keep in mind during treatment with choline fenofibrate include the following:
  • Contact your healthcare provider immediately if you experience any muscle pain, weakness, or tenderness while taking this medication, especially if accompanied by a fever or if you feel ill (see Trilipix and Muscle Pain).
  • Choline fenofibrate can cause increased liver enzymes, which can be a sign of liver problems, or high creatinine levels, which can be a sign of kidney problems. Both of these abnormalities are found using standard blood tests.
  • This medication may increase the risk of gallbladder disease, including gallstones.
  • Pancreatitis (inflammation of the pancreas) has been reported rarely in people taking choline fenofibrate or other similar medications. This could be a direct result of the medication or might simply be a complication of very high triglyceride levels (one of the conditions choline fenofibrate is used to treat).
  • Surprisingly, studies have suggested that medications similar to choline fenofibrate might actually increase the risk of death. It is not yet clear how this drug may affect the risk of death due to heart disease or other causes.
  • Studies have suggested that medications like choline fenofibrate might increase the risk of blood clots in the legs or lungs.
  • This product is a pregnancy Category C medicine, which means it may not be safe for use during pregnancy, although the full risks are currently unknown. If you are pregnant and taking choline fenofibrate, talk to your healthcare provider immediately (see Trilipix and Pregnancy).
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Choline Fenofibrate Information

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