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Brilinta Warnings and Precautions

Before taking Brilinta, tell your doctor if you will be having surgery or have any type of bleeding disorder. Because this is an antiplatelet drug, there are many precautions and warnings to keep in mind regarding the risk for major bleeding associated with Brilinta. This drug should not be used in people with active bleeding, severe liver disease, or certain allergies.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Brilinta™ (ticagrelor) if you have:
  • A bleeding disorder
  • Intestinal or stomach ulcers or bleeding
  • Bleeding in the brain
  • An aneurysm
  • Liver disease, such as liver failure or cirrhosis
  • Any allergies, including to food, dyes, or preservatives.
Also, let your healthcare provider know if you:
  • Will be having surgery
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Warnings and Precautions With Brilinta

Warnings and precautions to be aware of prior to taking this drug include the following:
  • One of the most serious Brilinta side effects is bleeding, including potentially fatal internal bleeding. This risk is higher for certain people, such as those who:
    • Have a bleeding disorder
    • Are taking other medications that increase the risk of bleeding
    • Are about to undergo an invasive procedure or surgery.
This drug should not be given to any individual with active bleeding.
  • Let your healthcare provider know if you develop any signs of bleeding, such as:
    • Easy bruising
    • Cuts or scrapes that are slow to stop bleeding
    • Black, tarry stools; bright-red blood in the stool; or vomiting of blood (signs of gastrointestinal bleeding)
    • Signs of bleeding in the brain, such as vision or speech changes, weakness or numbness in an arm or leg, or a severe headache.
  • Brilinta has not been studied in people with liver disease. Liver disease will likely increase the risk of dangerous Brilinta side effects, especially bleeding.
  • This drug should not be given to people who are likely to need heart bypass surgery. If a person already taking Brilinta needs to have a bypass, the procedure should be postponed for five days, if possible, in order to decrease the risk of life-threatening bleeding.
  • Brilinta may need to be stopped ahead of time for any elective surgery. Ask your healthcare provider when you should stop and restart the medication.
  • Brilinta often causes shortness of breath. This is not a particularly dangerous side effect. However, report any shortness of breath (or worsening of shortness of breath) to your healthcare provider, since it could be caused by something more serious.
  • This product may react with several different medications (see Brilinta Drug Interactions).
  • At this time, it is not entirely clear how long people should continue to take Brilinta, and different healthcare providers may have different opinions on this matter. Your healthcare provider will take into account your particular situation when recommending how long treatment should last. Stopping the drug too soon may increase your risk of heart attacks, blood clots in your stent, and death.
  • This medicine is a pregnancy Category C drug, which means that it may not be safe for use during pregnancy, although the full risks are currently unknown (see Brilinta and Pregnancy for more information).
  • At this time, it is unknown if Brilinta passes through breast milk in humans. If you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Brilinta and Breastfeeding for more information).
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