Drug Interactions With Amlodipine

A number of medications can react with amlodipine, including phenytoin, atazanavir, and indinavir. Amlodipine drug interactions can cause problems such as an increased risk of side effects or, in some cases, decreased drug effectiveness. Discussing your current medications with your healthcare provider will help ensure that amlodipine is right for your particular situation.

An Overview of Amlodipine Interactions

Amlodipine besylate (Norvasc^®) can potentially react with several other medications. Some of these medicines that may lead to amlodipine drug interactions include:

CYP 3A4 inducer medications, such as:
- Aminoglutethimide (Cytadren^®)
- Bosentan (Tracleer^®)
- Carbamazepine (Carbatrol^®, Epitol^®, Equetro^®, Tegretol^®)
- Dexamethasone (Decadron^®, Dexpak^®, Maxidex^®)
- Efavirenz (Sustiva^®)
- Efavirenz, emtricitabine, and tenofovir (Atripla^®)
- Etravirine (Intelence™)
- Fosphenytoin (Cerebyx^®)
- Nafcillin
- Nevirapine (Viramune^®)
- Oxcarbazepine (Trileptal^®)
- Pentobarbital (Nembutal^®)
- Phenobarbital (Luminal^®)
- Phenytoin (Dilantin^®, Phenytek^®)
- Primidone (Mysoline^®)
- Rifabutin (Mycobutin^®)
- Rifampin (Rifadin^®)
- Rifapentine (Priftin^®)
- St. John's wort

CYP 3A4 inhibitor medications, such as:
- Amprenavir (Agenerase^®)
- Atazanavir (Reyataz^®)
- Clarithromycin (Biaxin^®)
- Conivaptan (Vaprisol^®)
- Darunavir (Prezista^®)
- Delavirdine (Rescriptor^®)
- Diltiazem (Cardizem^®, Cardizem CD^®, Cardizem LA^®, Cartia XT^®, Dilacor XR^®, Dilt-CD^®, Diltia XT^®, Dilt-XR^®, Taztia XT^®, Tiazac^®)
- Erythromycin
- Fosamprenavir (Lexiva^®)
- Imatinib (Gleevec^®)
- Indinavir (Crixivan^®)
- Isoniazid
- Itraconazole (Sporanox^®)
- Ketoconazole (Nizoral^®)
- Lopinavir and ritonavir (Kaletra^®)
- Miconazole
- Nefazodone (Serzone^®)
- Nelfinavir (Viracept^®)
- Nicardipine (Cardene^®)
- Posaconazole (Noxafil^®)
- Quinidine
- Ritonavir (Norvir^®)
- Saquinavir (Fortovase^®, Invirase^®)
- Telithromycin (Ketek^®)
- Voriconazole (VFEND^®)

Simvastatin (Zocor^®) or combination medications that contain simvastatin (Juvisync^®, Simcor^®, Vytorin^®).

Drug Interactions With Amlodipine Article Continues on Next Page >

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD

Last reviewed by: Kristi Monson, PharmD

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