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Amiodarone Premixed Injection Dosage

The recommended starting dosage of amiodarone premixed injection is usually 1000 mg given as a continuous infusion over a 24-hour period. However, the specific amount will depend on how you respond to the medicine, the severity of your arrhythmia, and various other factors. Your healthcare provider will administer this injection in a hospital, where you can be closely monitored.

An Introduction to Your Dosage of Amiodarone Premixed Injection

The dose of amiodarone premixed injection (Nexterone®) your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • The severity of your arrhythmia
  • How you respond to the medication
  • Whether you develop side effects.
 
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
 

Recommended Dosing Guidelines

The recommended initial dosage of amiodarone premixed injection is usually 1000 mg given as a continuous infusion (a slow injection) over a 24-hour period. This initial dose is normally given as 150 mg over 10 minutes (15 mg per minute), followed by 360 mg over the next 6 hours (1 mg per minute), followed by 540 mg over the remaining 18 hours (0.5 mg per minute).
 
The initial amiodarone premixed injection dose may vary from person to person, depending on the individual's response to the medicine. However, doses above 2100 mg increase the risk for a potentially dangerous drop in blood pressure (hypotension), and should generally be avoided.
 
After the first 24 hours, the usual maintenance dose of 720 mg is given over 24 hours (0.5 mg per minute), which will continue until a healthcare provider determines the arrhythmia is adequately controlled. This usually takes two to four days; however, some people may need to continue the medicine for one to three weeks. Additional doses of 150 mg may be necessary to treat any breakthrough episodes of arrhythmia that occur during this time.
 
Once your arrhythmia is adequately controlled, your healthcare provider may recommend you start taking amiodarone tablets (Cordarone®, Pacerone®). Your initial recommended dosage of amiodarone tablets will depend on how long you received amiodarone premixed injections. The usual recommended dosage of amiodarone tablets is as follows:
 
  • 800 mg to 1600 mg for people who received amiodarone premixed injections for less than a week
  • 600 mg to 800 mg for people who received amiodarone premixed injections for one to three weeks
  • 400 mg for people who received amiodarone premixed injections for longer than three weeks.
 
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Amiodarone Premixed Injection Information

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